So recently they have delineated genetic markers for precursor conditions...
Whole-Genome Sequencing Identifies 2 Distinct Myeloma Precursor Conditions
"Whole-genome sequencing (WGS) has the potential to accurately differentiate between stable and progressive precursor conditions to multiple myeloma in low disease burden clinical states and the use of this technology in the clinic may result in a significant shift in the management of these patients, according to data from a study published in Nature Communications.
The distribution of genetic events reveals striking differences and the existence of 2 biologically and clinically distinct entities of asymptomatic monoclonal gammopathies: (i) one entity characterized by a sufficient number of myeloma genomic defining events to confer malignant potential and which is associated with progressive disease, and (ii) another entity with a lower burden of genetic events characterized by high likelihood of a prolonged, indolent, and clinically stable course
Going forward, improved and biology-oriented strategies to accurately identify patients with progressive myeloma precursor condition before clonal expansion (i) will allow earlier initiation of therapy before onset of end-organ damage to avoid severe clinical complications, (ii) will prevent patients with precursor conditions from being overtreated."
This is all over the place in blood cancer journals so I feel like this is important. If we can identify with a simple test who is in danger of progression and who isn't... we can treat someone BEFORE THEY GET A LOT OF CLONES. Right now, the danger of treating someone is what if the condition never gets any worse...
Imagine then if we could avoid the development of blood cancer for 20 to 30 years with just a simple treatment every 5 years or so? IMHO that would effectively end blood cancer.
Currently I have sent a lot of blood and data to the PC Crowd and Impact studies. I hope they are using it to test some of these theories out.
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