I have been thinking about this lately. It definitely seems that there are case studies on the books of MGUS going away. But why? Mostly it seems that the MGUS can go away once an infection subsides. For instance, Hepatitis C or an auto immune disorder.
But why?
My best guess would be that clonal plasma cells are called up along with normal cells to fight the problem... only to have the body terminate them once the threat is resolved. Ultimately the problem might not be resolved as eventually MGUS might come back. We simply don't know.
So I was thinking about it and it seems to me that one way to avoid the progression of MGUS is to avoid getting any sort of infection and to end your inflammation.
In theory, MGUS is a break down in the Hemotropic Stem Cells. Inflammation causes the Hemotropic Stem Cells to break at a gene that controls differentiation of plasma cells. Thus, in theory, if your body has need to call up plasma cells to fight an infection... you could be left with Clonal Proliferation which may -- or may not -- die once the infection is gone.
Further, it seems like if you can end the inflammation that is causing the damage to the Hemotropic Stem Cells... and also NOT GET AN INFECTION... your body may naturally dispose of the MGUS as any new cells will be made from healthy Hemotropic Stem Cells and the Clones cannot necessarily live forever.
